Tillipirosin
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Tillipirosin
I-Tilipirosin luhlobo olusha lwendandatho ye-Macrolide ye-MacTolide eyi-16 ye-Mevide engu-16 ye-16 ye-MACOLIDE yezilwane, okuyinto esuselwa eTylosin.
Isenzo samakhemisi
Umphumela we-antibacterial we-tiltipirosin ufana neye-tylosin, futhi unomphumela onamandla wokuvimbela kumagciwane ane-gram-positive namanye amagciwane angenamagagasi. Indlela ye-antibacterial of tillipirosin iyafana neyama-macrolides. Ingahlanganisa ne-subunit yama-50s ye-ribosome yama-bacterio abucayi ukuze ivimbise ukuhlanganiswa kwamaketanga we-ribains ama-rains, ngaleyo ndlela kuthinte ukuhlanganiswa kwamaprotheni amagciwane. Ukuxhumana kwezakhi ezimbili ze-piperidine ezihlukile ku-tillipirosin kuhlukanisa indlela yokusebenza kwalesi sidakamizwa kusuka ku-tylosin kanye ne-tilmicosin, lapho ama-20-piperidine aqondiswe ku-lumen ukuphazamisa ukukhula kwama-peptides ama-nascent.
Ngoba i-tediroxine inamaqembu amathathu ayisisekelo ama-amino, angakha amafomu ahlukene akhokhisiwe ngaphansi kwezimo ezahlukahlukene ze-PH. Inani lemali ekhokhwayo liyisici esibalulekile sokubhubhisa i-solubility yama-bacteri ama-lipids futhi ungene ngaphakathi kwamagciwane e-gram-amabi, ngakho-ke umsebenzi we-bacteriostatic we-tiltipirosin e-vitro uthintwe kakhulu i-pH. Ngaphansi kwezimo ze-acidic, iqembu le-amino livikelwe, liphumela ekwehliseni emsebenzini we-antibacterial we-tediroxine, ngenkathi ngaphansi kwezimo ze-alkaliwe, inomsebenzi onamandla wokulwa ne-antibacterial.
Ama-Macrolides avimbela ukutholakala kwama-cytokines proinfaration, umsebenzi we-phospholipase, kanye nokukhishwa kwe-leukotriene, futhi ube nemiphumela yokulwa nokuvuvukala kuma-macrophages nama-neutrophils. I-Tediroxine inciphisa amalansikazi okuvuvukala akhiqizwa ngesikhathi sokuvuvukala okuthile noma ukucindezela.
I-antibacterial spectrum
I-Tilipirosin iyasebenza ngokulwa namagciwane e-paitogenic adala izifo zokuphefumula ezingulubeni nasezinkomeni (njenge-pasteurella multrocida, i-actetobacillo plasurneumoniae, i-acretophas bronsuptica, i-actheemophilus parasuis, i-mannheim spp, i-mannheim spp. Njll. Njll. Njp. I-Tilmicosin, kanye nomsebenzi we-antibacterial okulwa namathumbu escherhia Coli ayengcono kuneTylosin neTilmicosin. Kuyazwela futhi ezinye izinhlobo ze-Mycoplasma, i-Spirochetes, i-BrucuelTa, njll. Izifundo zikhombise ukuthi iTediroxine inamandla we-bacteriostatic umphumela we-haemophilus ne-bleuterobacilptis e-acteuropneoniae kanye ne-pasteurella multropnea. I-Tilipirosin i-bactericidal kwamanye amagciwane (njenge-haemophilus parasuis kanye ne-actinobacillus Pleuropneumoniae), kuyilapho ikakhulukazi i-bacteriostatic kumagciwane athile (njenge-pasteurella multocida). Kumagciwane emathunjini, ngokuncipha kwenani le-PH (kusuka ku-7.3 kuye ku-6.7), i-mic of tilpirosin yandise, ngokwesibonelo, i-mic of tilpirosin ebhekene ne-salmonella enteritidis no-86ug / m kuya ku-64 ~ 256ug / ml. Ngakho-ke, umphumela wezinguquko ze-PH eVivo kufanele ubhekwe lapho uqhuba ukuhlolwa kwe-Vivo antibacterial of tilliposin. Ngaphezu kwalokho, i-mic of tilpirosin ebhekene nezinhlobo ezijwayelekile ze-pasteurella multrocida kwakungu-0.5ug / ml ku-serum, okwakungama-0.25 times aphansi kunalokho e-vitro, okungahle kuhlobane ne-serum umphumela.
I-Enterococcus-Strettococcus ezinkomeni zobisi imelana kakhulu neTediroxine. I-Tilipirosin ayizwakali ku-pasteurella multrocida kanye neMannziimia haemolyticus ephethe izinhlobo zofuzo. Ngokufanayo, izinhlobonhlobo zofuzo eziguqulwe ngofuzo lukaM. Bovis zimelana nama-macrolide antibistosics kubandakanya i-tiltipirosin. Izingqinamba ezithile zeHaemophilus Parasuis nazo zitholwe zimelana ngokwemvelo eTediroxine. I-MyCoplasma Bovis ingathola ngokushesha ukumelana noTildipirosin, kepha ngenxa yokukhula kancane kwe-MyCoplasma, ukuhlolwa kwe-Vitro Drug Ukuhlola Ukuqina kungabambezela ukwelashwa. Ucwaningo lukhombisile ukuthi isizinda II (i-nucleotide 748) kanye ne-Domain v (izinguquko ze-nucleotides 2059 no-2060) zihlotshaniswa nokuphikiswa okwengeziwe kuma-macrolides. Ngakho-ke, ukuthambekela kukaM. Bovis emithini yeMacoRide kungatholakala ngokushesha ngokuhlolwa kwamangqamuzana kwalokhu kuguqulwa.
-Delile
≥ 98%
Ukucacisa
Inkampani yenkampani
UHebei Veyong Pharmaceutical Co, Ltd, wasungulwa ngonyaka ka-2002, etholakala eShijiazhuang City, esifundeni saseHebei, eChina, eduze kwenhloko-dolobha eBeijing. Uyibhizinisi elikhulu lezidakamizwa eliqinisekisiwe le-GMP, nge-R & D, ukukhiqizwa kanye nokuthengiswa kwama-apis wezilwane, amalungiselelo, okuphakelayo okubekiwe kanye nokuphakelwa izengezo. Njengesikhungo sezobuchwepheshe sesifundazwe, uVeyong usungule uhlelo olusha lwe-R & D lwe-New Veterinary Drug, futhi yiwona we-technological annology ebhizinisini elisuselwa kubuchwepheshe, kukhona ochwepheshe bezobuchwepheshe abangama-65. UVeyong unezisekelo ezimbili zokukhiqiza: I-Shijuazhuang kanye ne-Ordos, lapho iShijuazhuange isiza ifaka indawo engu-78,706 m2, i-Oxytetracycline imigqa yokukhiqiza kubandakanya i-ivermectin, i-olytetracycline imigqa yokukhiqiza kubandakanya umjovo, i-bolus, ama-pesticides kanye amagciwane, amahlelo. UVeyong unikeza ama-API, amalungiselelo angaphezu kwe-100 anamalebula, kanye nensizakalo ye-OEM & ODM.
UVeyong unamathela ngokubaluleka okukhulu ekuphathweni kwe-EHS (imvelo, ezempilo kanye nokuphepha), futhi uthole izitifiketi ze-ISO14001 nezi- ohsas180000. UVeyong ubhalwe phansi kumabhizinisi wezimboni asafufusa izimboni esifundazweni saseHebei futhi angaqinisekisa ukunikezwa kwemikhiqizo okuqhubekayo.
UVeyong wasungula uhlelo oluphelele lokuphathwa kwekhwalithi, ethola isitifiketi se-ISO9001, isitifiketi se-China GMP, isitifiketi se-APHVMA GMP, isitifiketi se-Ethiopia GMP, isitifiketi se-Ivermectin CEP, futhi sadlula ukuhlolwa kwe-US FDA. UVeyong uneqembu eliqeqeshiwe lokurejista, ukuthengisa kanye nenkonzo yezobuchwepheshe, inkampani yethu ithole ukuthembela nokusekelwa okuvela kumakhasimende amaningi ngekhwalithi ephezulu yomkhiqizo, insizakalo ephezulu yokuthengisa kanye nokuthengisa okuthengiswayo, ukuphathwa okungathi sína. UVeyong wenze ukubambisana isikhathi eside ngamabhizinisi amaningi ezaziwayo ezingezemikhiqizo athunyelwe eYurophu, eSouth America, eMpumalanga Ephakathi, e-Eshiya, e-ESIA, amazwe angaphezu kwangu-60.
