I-Tildidirosin

Incazelo emfushane:

I-CAS:328898-40-4

Isitifiketi:I-GMP ne-ISO

Ukupakisha:25kg/isigubhu

Isampula:Iyatholakala

Imali yokuthengisa ye FOB	US $0.5 – 9,999 / Ucezu
Inani elincane le-oda	1 Ucezu/Izingcezu
Supply Amandla	10000 Ucezu/Izingcezu Ngenyanga
Isikhathi sokukhokha	T/T, D/P, D/A, L/C

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Iphrofayela Yenkampani

Omaka bomkhiqizo

I-Tildidirosin

I-Tildipirosin iwuhlobo olusha lwe-semi-synthetic 16-membered ring macrolide antibiotic yezilwane, ephuma ku-tylosin.

Isenzo se-Pharmacological

Umphumela we-antibacterial we-Tildidirosin ufana nowe-tylosin, futhi unomphumela oqinile wokuvimbela amabhaktheriya e-Gram-positive kanye namanye amagciwane e-Gram-negative.Indlela ye-antibacterial ye-Tildidirosin iyafana neyama-macrolides.Ingahlangana ne-50S subunit ye-ribosome yamagciwane azwelayo ukuvimbela ukuhlanganiswa kwamaketanga e-riboprotein peptide, ngaleyo ndlela kuthinte ukuhlanganiswa kwamaprotheni ebhaktheriya.Ukusebenzisana kwezingxenye ezimbili ze-piperidine eziyingqayizivele ku-Tildidirosin kuhlukanisa indlela yokusebenza yalesi sidakamizwa kusuka ku-tylosin ne-tilmicosin, lapho i-20-piperidine iqondiswe ku-lumen ukuze iphazamise ukukhula kwama-peptide asanda kuzalwa.

Ngenxa yokuthi i-tediroxine inamaqembu ama-amino ayisisekelo angu-3, ingenza amafomu ahlukene akhokhiswe ngaphansi kwezimo ze-pH ezihlukene.Inani lenkokhiso liyisici esibalulekile sokubhubhisa ukuncibilika kwe-lipids yebhaktheriya futhi lingene kulwelwesi lwangaphandle lwe-Gram-negative bacteria, ngakho-ke umsebenzi we-bacteriostatic we-Tildidirosin in vitro uthintwa kakhulu yi-pH.Ngaphansi kwezimo ezine-acidic, iqembu le-amino li-protonated, okuholela ekwehleni komsebenzi we-antibacterial we-tediroxine, kuyilapho ngaphansi kwezimo ze-alkali, inomsebenzi onamandla we-antibacterial.

Ama-Macrolides avimbela ukugcinwa kwama-cytokines e-proinflammatory, umsebenzi we-phospholipase, nokukhululwa kwe-leukotriene, futhi abe nemiphumela yokulwa nokuvuvukala kuma-macrophages nama-neutrophils.I-Tediroxine inciphisa abalamuli bokuvuvukala abakhiqizwa ngesikhathi sokuphendula okuthile kokuvuvukala noma kwengcindezi.

I-antibacterial spectrum

I-Tildipirosin iyasebenza ngokumelene namabhaktheriya e-pathogenic abangela izifo zokuphefumula ezingulubeni nasezinkomeni (njenge-Pasteurella multocida, Actinobacillus pleuropneumoniae, Bordetella bronchiseptica, Haemophilus parasuis, Mannheim spp. njll.) umsebenzi we-antibacterial we-tilmicosin wawuphakeme izikhathi ezingu-2-32 kunalowo we-tilmicosin , kanye nomsebenzi wokulwa namagciwane ngokumelene namathumbu e-Escherichia coli wawungcono kune-tylosin ne-tilmicosin.Izwela futhi kwezinye izinhlobo ze-mycoplasma, ama-spirochetes, i-brucella, njll. Ucwaningo lubonise ukuthi i-tediroxine inomphumela onamandla we-bacteriostatic ku-Haemophilus parasuis ne-Bordetella bronchiseptica kune-florfenicol, kodwa umphumela we-bacteriostatic obuthakathaka ku-Actinobacillus pleuropneumoniae ne-Pasteurella multocida.I-Tildipirosin ibulala amagciwane kwamanye amagciwane (afana ne-Haemophilus parasuis kanye ne-Actinobacillus pleuropneumoniae), kuyilapho ikakhulukazi i-bacteriostatic kwamanye amagciwane (afana ne-Pasteurella multocida).Kumagciwane amathumbu, ngokuncipha kwenani le-pH (kusuka ku-7.3 kuya ku-6.7), i-MIC ye-Tildidirosin yanda, isibonelo, i-MIC ye-Tildipirosin ngokumelene ne-Salmonella Enteritidis ne-Escherichia coli ingakhuphuka isuka ku-2 ~ 8ug/m iye ku-64~256ug/mL. .Ngakho-ke, umphumela wezinguquko ze-pH ku-vivo kufanele ucatshangelwe lapho kwenziwa ukuhlolwa kwe-in vivo antibacterial ye-Tildidirosin.Ngaphezu kwalokho, i-MIC ye-Tildidirosin ngokumelene nezinhlobo ezijwayelekile ze-Pasteurella multocida yayingu-0.5ug/mL ku-serum, eyayingaphansi izikhathi ezingu-0.25 kunaleyo ye-in vitro, okungenzeka ihlotshaniswe nomphumela we-serum.

I-Enterococcus-Streptococcus ezinkomeni zobisi imelana kakhulu ne-tediroxine.I-Tildipirosin ayizweli ku-Pasteurella multocida kanye ne-Mannheimia haemolyticus ephethe izakhi zofuzo eziguqukayo.Ngokunjalo, izinhlobo eziguquguqukayo zofuzo ze-M. bovis azikwazi ukumelana nama-macrolide antibiotics kuhlanganise ne-Tildidirosin.Izinhlobo ezithile ze-Haemophilus parasuis nazo zitholakale zikwazi ukumelana ne-tediroxine ngokwemvelo.I-Mycoplasma bovis ingathola ngokushesha ukumelana ne-Tildidirosin, kodwa ngenxa yokukhula kancane kwe-Mycoplasma, ukuhlolwa kwezidakamizwa ze-in vitro kungase kubambezele ukwelashwa.Ucwaningo luye lwabonisa ukuthi isizinda II (i-nucleotide 748) kanye nesizinda V (Ukuguqulwa kwe-nucleotides 2059 no-2060) kuhlotshaniswa nokwanda kokumelana nama-macrolides.Ngakho-ke, ukuba sengozini kwe-M. bovis emithini ye-macrolide kungatholwa ngokushesha ngokuhlolwa kwamangqamuzana alokhu kuguquka.

Okuqukethwe

≥ 98%

Ukucaciswa

Izinga lenkampani

Okwedlule: I-Tilmicosin Phosphate

Olandelayo: I-Vitamin B Premix

I-Hebei Veyong Pharmaceutical Co., Ltd, yasungulwa ngo-2002, etholakala eShijiazhuang City, eSifundazweni saseHebei, eChina, eduze kweNhloko-dolobha yaseBeijing.Uyibhizinisi elikhulu lemithi yezilwane eqinisekiswe yi-GMP, ene-R&D, ukukhiqizwa nokudayiswa kwama-API wezilwane, amalungiselelo, okuphakelayo okuxutshwe ngaphambili nezithasiselo zokudla.NjengeSikhungo Sezobuchwepheshe Sesifundazwe, i-Veyong isungule uhlelo olusha lwe-R&D lomuthi omusha wezilwane, futhi iyibhizinisi lezobuchwepheshe elaziwa kuzwelonke elisekelwe kudokotela wezilwane, kunochwepheshe abangama-65.I-Veyong inezisekelo ezimbili zokukhiqiza: i-Shijiazhuang ne-Ordos, lapho isisekelo se-Shijiazhuang sihlanganisa indawo engu-78,706 m2, nemikhiqizo ye-API engu-13 ehlanganisa i-Ivermectin, i-Eprinomectin, i-Tiamulin Fumarate, i-Oxytetracycline hydrochloride ects, kanye ne-11, imigqa yokukhiqiza ye-powder yokulungiselela , premix, bolus, izibulala-zinambuzane nesibulala-magciwane, njll.I-Veyong ihlinzeka ngama-API, amalungiselelo angaphezu kwe-100 elebula uqobo, kanye nesevisi ye-OEM & ODM.

I-Veyong ibheka ukubaluleka okukhulu ekuphathweni kohlelo lwe-EHS(Imvelo, Impilo Nokuphepha), futhi yathola izitifiketi ze-ISO14001 ne-OHSAS18001.I-Veyong isohlwini lwamasu amabhizinisi ezimboni asafufusa esifundazweni sase-Hebei futhi ingaqinisekisa ukuhlinzekwa okuqhubekayo kwemikhiqizo.

I-Veyong yasungula uhlelo oluphelele lokuphatha ikhwalithi, yathola isitifiketi se-ISO9001, isitifiketi se-China GMP, isitifiketi se-APVMA GMP yase-Australia, isitifiketi se-Ethiopia GMP, isitifiketi se-Ivermectin CEP, futhi yaphumelela ukuhlolwa kwe-US FDA.I-Veyong inethimba elichwepheshile lokubhalisa, ukuthengisa kanye nenkonzo yezobuchwepheshe, inkampani yethu ithole ukwethenjwa nokusekelwa kumakhasimende amaningi ngekhwalithi yomkhiqizo omuhle kakhulu, ikhwalithi ephezulu yokuthengisa kwangaphambili kanye nenkonzo yangemuva kokuthengisa, ukuphathwa okungathi sína nokwesayensi.I-Veyong yenze ukubambisana kwesikhathi eside namabhizinisi amaningi emithi yezilwane aziwa emhlabeni wonke ngemikhiqizo ethunyelwa eYurophu, eNingizimu Melika, eMpumalanga Ephakathi, e-Afrika, e-Asia, njll. emazweni nasezifundeni ezingaphezu kuka-60.