4% umjovo we-Gentamyclin sulphate
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Inkomba
Ukubukeka:Lo mkhiqizo awunambala kuya kokuphuzi noma okuphuzi okuluhlaza okoketshezi olucacile.
Isenzo se-Pharmacological:I-PharmacodynamicI-Gentamyciniyimithi elwa namagciwane ye-aminoglycoside enomphumela we-antibacterial ezinhlobonhlobo zamagciwane angenayo igram (njenge-Escherichia coli, i-Klebsiella, i-Proteus, i-Pseudomonas aeruginosa, i-Pasteurella, i-Salmonella, njll.) kanye ne-Staphylococcus aureus (kuhlanganise ne-β-lacingstrains-pro).Iningi le-cocci (Streptococcus pyogenes, pneumococcus, Streptococcus faecalis, njll.), amagciwane anaerobic (Bacteroides noma Clostridium), Mycobacterium tuberculosis, Rickettsia kanye nesikhunta amelana nalo mkhiqizo.
I-Pharmacokinetics:Ukumuncwa kuyashesha futhi kuphelele ngemuva komjovo we-intramuscular.Ukugxila okuphezulu kufinyelelwa phakathi kwehora elingu-0.5 kuye ku-1.I-Bioavailability idlula ama-90% ngomjovo ongaphansi kwesikhumba noma we-intramuscular.Ikhishwa ikakhulukazi ngokuhlunga kwe-glomerular futhi ibalelwa ku-40% kuya ku-80% womthamo olawulwayo.Isigamu sempilo ngemuva komjovo we-intramuscular singamahora angama-1.8 kuye kwangama-3.3 emahhashini, amahora angama-2.2 kuye kwangama-2.7 ematholeni, amahora angama-0.5 kuye kwayi-1.5 ezinjeni namakati, ihora eli-1 ezinkomeni nasezingulubeni, ihora eli-1 kuye kwangama-2 onogwaja, kanye namahora angama-2.3 kuye kwangama-3.2. amahora ezimvu, izinyathi, izinkomo, nezimbuzi zobisi.
Ukusebenzisana kwezidakamizwa:
(1) Inhlanganisela ye-Gentamycin ne-tetracycline ne-erythromycin ingase ibe nomphumela ophikisayo.
(2) Ngokuhambisana ne-cephalosporins, i-dextran, i-diuretics enamandla (njenge-furosemide, njll.), ne-erythromycin, i-ototoxicity yalo mkhiqizo ingathuthukiswa.
(3) Iziphumuli zemisipha yamathambo (njenge-succinylcholine chloride, njll.) noma izidakamizwa ezinalo mphumela zingathuthukisa umphumela wokuvimbela i-neuromuscular we-HUMIRA.
Isenzo nokusetshenziswa
Ama-antibiotic e-aminoglycoside.Ngezifo zebhaktheriya ezine-Gram-negative kanye ne-positive.
Umthamo kanye nokuphatha
(1) I-Ototoxicity.Ngokuvamile kubangela ukulimala kwe-vestibular endlebeni, okungase kubhebhetheke ngokuqoqwa kwezidakamizwa ezilawulwa ngokuqhubekayo ngendlela encike kumthamo.
(2) Ukungezwani komzimba ngezikhathi ezithile.Amakati azwela kakhulu, angaguquki angabangela isicanucanu, ukuhlanza, amathe kanye ne-ataxia.
(3) Amanani aphezulu angabangela ukuvinjelwa kwe-neuromuscular conduction.Ukufa ngengozi kuvame ukwenzeka ngemva kokulaliswa kwezinzwa okuvamile kwezinqubo zokuhlinzwa ezinjeni namakati, kuhlanganiswe ne-penicillin ukuvimbela ukutheleleka.
(4) Ingabangela i-nephrotoxicity ehlehlayo.
Izinyathelo zokuzivikela
(1) I-Gentamycin ingasetshenziswa kanye nemithi elwa namagciwane i-β-lactam ukwelapha izifo ezinzima, kodwa ayihambisani uma ixutshwa ku-vitro.
(2) Ngokuhambisana ne-penicillin, lo mkhiqizo unomphumela we-synergistic ku-streptococci.
(3) Inokucindezeleka kokuphefumula futhi akufanele ijovwe ngomjovo.
(4) Ukuphikisana kungase kwenzeke ngokuhambisana ne-tetracycline ne-erythromycin.
(5) Ukuhlanganiswa nama-cephalosporins kungase kuthuthukise i-nephrotoxicity.
Isikhathi sokuhoxa
Ingulube, inkomo nezimvu izinsuku ezingama-40.
Isitoreji
Ivalwe futhi igcinwe endaweni emnyama epholile.
I-Hebei Veyong Pharmaceutical Co., Ltd, yasungulwa ngo-2002, etholakala eShijiazhuang City, eSifundazweni saseHebei, eChina, eduze kweNhloko-dolobha yaseBeijing.Uyibhizinisi elikhulu lemithi yezilwane eqinisekiswe yi-GMP, ene-R&D, ukukhiqizwa nokudayiswa kwama-API wezilwane, amalungiselelo, okuphakelayo okuxutshwe ngaphambili nezithasiselo zokudla.NjengeSikhungo Sezobuchwepheshe Sesifundazwe, i-Veyong isungule uhlelo olusha lwe-R&D lomuthi omusha wezilwane, futhi iyibhizinisi lezobuchwepheshe elaziwa kuzwelonke elisekelwe kudokotela wezilwane, kunochwepheshe abangama-65.I-Veyong inezisekelo ezimbili zokukhiqiza: i-Shijiazhuang ne-Ordos, lapho isisekelo se-Shijiazhuang sihlanganisa indawo engu-78,706 m2, nemikhiqizo ye-API engu-13 ehlanganisa i-Ivermectin, i-Eprinomectin, i-Tiamulin Fumarate, i-Oxytetracycline hydrochloride ects, kanye ne-11, imigqa yokukhiqiza ye-powder yokulungiselela , premix, bolus, izibulala-zinambuzane nesibulala-magciwane, njll.I-Veyong ihlinzeka ngama-API, amalungiselelo angaphezu kwe-100 elebula uqobo, kanye nesevisi ye-OEM & ODM.
I-Veyong ibheka ukubaluleka okukhulu ekuphathweni kohlelo lwe-EHS(Imvelo, Impilo Nokuphepha), futhi yathola izitifiketi ze-ISO14001 ne-OHSAS18001.I-Veyong isohlwini lwamasu amabhizinisi ezimboni asafufusa esifundazweni sase-Hebei futhi ingaqinisekisa ukuhlinzekwa okuqhubekayo kwemikhiqizo.
I-Veyong yasungula uhlelo oluphelele lokuphatha ikhwalithi, yathola isitifiketi se-ISO9001, isitifiketi se-China GMP, isitifiketi se-APVMA GMP yase-Australia, isitifiketi se-Ethiopia GMP, isitifiketi se-Ivermectin CEP, futhi yaphumelela ukuhlolwa kwe-US FDA.I-Veyong inethimba elichwepheshile lokubhalisa, ukuthengisa kanye nenkonzo yezobuchwepheshe, inkampani yethu ithole ukwethenjwa nokusekelwa kumakhasimende amaningi ngekhwalithi yomkhiqizo omuhle kakhulu, ikhwalithi ephezulu yokuthengisa kwangaphambili kanye nenkonzo yangemuva kokuthengisa, ukuphathwa okungathi sína nokwesayensi.I-Veyong yenze ukubambisana kwesikhathi eside namabhizinisi amaningi emithi yezilwane aziwa emhlabeni wonke ngemikhiqizo ethunyelwa eYurophu, eNingizimu Melika, eMpumalanga Ephakathi, e-Afrika, e-Asia, njll. emazweni nasezifundeni ezingaphezu kuka-60.
