10% Umjovo we-Enrofloxacin
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Ividiyo
Isenzo se-Pharmacological
I-Enrofloxacin iyi-ejenti ebanzi ye-bactericidal yezilwane ze-fluoroquinolone.Okwe-Escherichia coli, i-Salmonella, i-Klebsiella, i-Brucella, i-Pasteurella, i-Actinobacillus pleuropneumoniae, i-Erysipelas, i-Proteus, i-Serratia marcescens, i-Corynebacterium pyogenes, i-Porter's sepsis Bacteria, i-Staphylococcus aureus, i-Mycoplasmasdia, njll ibe nemiphumela emihle ye-Chhlamydia, i-Chlamycoccus, njll. kanye ne-Streptococcus, kanye nemiphumela ebuthakathaka kubhaktheriya anaerobic.Inomphumela osobala we-antibacterial kuma-bacterium abucayi.Indlela yokusebenza ye-antibacterial yalo mkhiqizo ukuvimbela i-DNA gyrase yebhaktheriya futhi iphazamise ukuphindaphindeka kwe-DNA yebhaktheriya, ukuloba nokulungisa nokuhlanganisa kabusha.Amabhaktheriya awakwazi ukukhula futhi azalane ngokujwayelekile futhi afe.
I-Pharmacokinetics
10% Umjovo we-Enrofloxacinimuncwa ngokushesha nangokuphelele ngomjovo we-intramuscular.I-bioavailability yalo mkhiqizo ingu-91.9% ezingulubeni kanye nama-82% ezinkomo zobisi.Isatshalaliswa kabanzi ezilwaneni futhi ingangena kahle ezicutshini.Ngaphandle koketshezi lwe-cerebrospinal, ukugcwala komuthi cishe kuzo zonke izicubu kuphezulu kunalokho okuse-plasma.I-metabolism yesibindi ngokuyinhloko iwukukhipha iqembu le-ethyl lendandatho engu-7-piperazine ukuze kukhiqizwe i-ciprofloxacin, kulandelwa i-oxidation ne-glucuronic acid ebophayo.Ikhishwa ikakhulukazi ngezinso (ngokukhishwa kwe-renal tubular secretion kanye nokuhlunga kwe-glomerular), futhi i-15% ~ 50% ikhishwa emchameni ngendlela yayo yokuqala.Ingxenye yempilo yokuqedwa iyahluka kakhulu phakathi kwezinhlobo ezahlukene zezilwane kanye nemizila yokuphatha eyahlukene.Isigamu sempilo ngemuva kokujova nge-intramuscular singamahora angama-5.9 ezinkomeni, amahora angama-9.9 wamahhashi, amahora ayi-1.5 kuye kwangama-4.5 ezimvini, namahora angama-4.6 ezingulubeni.
Ukusebenzisana
(1)10% umjovo Enrofloxacinisetshenziswa ngokuhlanganiswa nama-aminoglycosides noma i-penicillin ebanzi, enomphumela we-synergistic.
(2) Ama-ion ensimbi esindayo afana ne-Ca2+, Mg2+, Fe3+ kanye ne-Al3+ angakwazi uku-chelate ngalo mkhiqizo futhi athinte ukumuncwa.
(3) Uma kuhlanganiswa ne-theophylline ne-caffeine, kunganciphisa izinga lokubopha amaprotheni e-plasma, kukhuphule ngokungavamile ukugcwala kwe-theophylline ne-caffeine egazini, futhi kubangele ngisho nezimpawu zobuthi be-theophylline.
(4) Lo mkhiqizo unomphumela wokuvimbela ama-enzyme ezidakamizwa zesibindi, anganciphisa izinga lokusulwa kwezidakamizwa ezigaywe kakhulu esibindini futhi andise ukugcwala kwezidakamizwa egazini.
Umsebenzi kanye nokusetshenziswa
Izidakamizwa ze-antibacterial fluoroquinolone.Isetshenziselwa izifo ezibangelwa amagciwane kanye nezifo ze-mycoplasma emfuyweni nasezinkukhuni
Umthamo kanye nokuphatha
Umjovo we-Intramuscular: umthamo owodwa, isisindo somzimba esingu-1kg, 0.025ml wezinkomo, izimvu nezingulube;0.025~0.05ml wezinja, amakati, nonogwaja.Sebenzisa izikhathi ezi-1 kuye kwezi-2 ngosuku izinsuku ezi-2 kuye kwezi-3.
Ukusabela okubi
(1) Ukuwohloka kwe-cartilage ezilwaneni ezincane, okuthinta ukuthuthukiswa kwamathambo futhi kubangele i-claudication nobuhlungu.
(2) Ukusabela kwesimiso sokugaya ukudla kuhlanganisa ukuhlanza, ukuphelelwa isifiso sokudla, nesifo sohudo.
(3) Ukusabela kwesikhumba kuhlanganisa i-erythema, ukulunywa, i-urticaria kanye ne-photosensitivity.
(4) Ukungezwani komzimba, i-ataxia, nokuquleka kubonakala ngezikhathi ezithile ezinjeni nasemakati.
I-Hebei Veyong Pharmaceutical Co., Ltd, yasungulwa ngo-2002, etholakala eShijiazhuang City, eSifundazweni saseHebei, eChina, eduze kweNhloko-dolobha yaseBeijing.Uyibhizinisi elikhulu lemithi yezilwane eqinisekiswe yi-GMP, ene-R&D, ukukhiqizwa nokudayiswa kwama-API wezilwane, amalungiselelo, okuphakelayo okuxutshwe ngaphambili nezithasiselo zokudla.NjengeSikhungo Sezobuchwepheshe Sesifundazwe, i-Veyong isungule uhlelo olusha lwe-R&D lomuthi omusha wezilwane, futhi iyibhizinisi lezobuchwepheshe elaziwa kuzwelonke elisekelwe kudokotela wezilwane, kunochwepheshe abangama-65.I-Veyong inezisekelo ezimbili zokukhiqiza: i-Shijiazhuang ne-Ordos, lapho isisekelo se-Shijiazhuang sihlanganisa indawo engu-78,706 m2, nemikhiqizo ye-API engu-13 ehlanganisa i-Ivermectin, i-Eprinomectin, i-Tiamulin Fumarate, i-Oxytetracycline hydrochloride ects, kanye ne-11, imigqa yokukhiqiza ye-powder yokulungiselela , premix, bolus, izibulala-zinambuzane nesibulala-magciwane, njll.I-Veyong ihlinzeka ngama-API, amalungiselelo angaphezu kwe-100 elebula uqobo, kanye nesevisi ye-OEM & ODM.
I-Veyong ibheka ukubaluleka okukhulu ekuphathweni kohlelo lwe-EHS(Imvelo, Impilo Nokuphepha), futhi yathola izitifiketi ze-ISO14001 ne-OHSAS18001.I-Veyong isohlwini lwamasu amabhizinisi ezimboni asafufusa esifundazweni sase-Hebei futhi ingaqinisekisa ukuhlinzekwa okuqhubekayo kwemikhiqizo.
I-Veyong yasungula uhlelo oluphelele lokuphatha ikhwalithi, yathola isitifiketi se-ISO9001, isitifiketi se-China GMP, isitifiketi se-APVMA GMP yase-Australia, isitifiketi se-Ethiopia GMP, isitifiketi se-Ivermectin CEP, futhi yaphumelela ukuhlolwa kwe-US FDA.I-Veyong inethimba elichwepheshile lokubhalisa, ukuthengisa kanye nenkonzo yezobuchwepheshe, inkampani yethu ithole ukwethenjwa nokusekelwa kumakhasimende amaningi ngekhwalithi yomkhiqizo omuhle kakhulu, ikhwalithi ephezulu yokuthengisa kwangaphambili kanye nenkonzo yangemuva kokuthengisa, ukuphathwa okungathi sína nokwesayensi.I-Veyong yenze ukubambisana kwesikhathi eside namabhizinisi amaningi emithi yezilwane aziwa emhlabeni wonke ngemikhiqizo ethunyelwa eYurophu, eNingizimu Melika, eMpumalanga Ephakathi, e-Afrika, e-Asia, njll. emazweni nasezifundeni ezingaphezu kuka-60.
