20% Albendazole Granule
I-Pharmacology
I-Albendazole iphuma kubenzimidazole, engase igaywe ngokushesha emzimbeni ibe yi-sulfoksidi, i-sulfone alcohol kanye ne-2-aminosulfone alcohol.Ivimbela ngokukhethayo futhi ngendlela engenakuhlehliswa i-polymerization yesistimu ye-cytoplasmic microtubule yamaseli odonga lwamathumbu e-parasite ye-nematodes yamathumbu, engavimbela ukumuncwa nokumuncwa kwezinhlobonhlobo zezakhamzimba kanye ne-glucose, okuholela ekuphelelweni kwe-endogenous glycogen ezinambuzaneni, i-fumarate reductase Uhlelo luvimbela ukukhiqizwa kwe-adenosine triphosphate futhi luvimbele ukusinda nokukhiqizwa kabusha kwesikelemu.Ngokufanayo ne-mebendazole, lo mkhiqizo ungase futhi ubangele ukuwohloka kwe-cytoplasmic microtubules yamangqamuzana amathumbu esibungu, futhi ubophe ku-tubulin yayo, okubangela ukuvinjelwa kokuthutha okungaphakathi kwe-intracellular, okubangela ukunqwabelana kwama-Golgi endocrine granules, ukuqedwa kancane kancane kwe-cytoplasmic, kanye nokuwohloka okuphelele kokumuncwa. amaseli.Ibangela ukufa kwesibungu.20% Albendazole granuleingawabulala ngokuphelele amaqanda e-hookworm namaqanda omsundu futhi ingxenye yawo ibulale amaqanda ezikelemu.Ngaphezu kokubulala nokuxosha ama-nematode ahlukahlukene angama-parasitic ezilwaneni, futhi inemiphumela esobala yokubulala nokuxosha kuma-tapeworms kanye ne-cysticercus.
I-Toxicology
Ukuhlolwa kwe-toxicological kubonisa ukuthi lo mkhiqizo unobuthi obuphansi futhi uphephile.I-LD50 yomlomo yamagundane inkulu kuno-800mg/kg, futhi umthamo omkhulu obekezeleleka wezinja ungaphezu kuka-400mg/kg.Lesi sidakamizwa asinawo umthelela emsebenzini wokuzala wamagundane abesilisa, futhi awunawo umphumela we-teratogenic kumagundane wesifazane.Ukumuncwa kwengane kungase kwenzeke lapho umthamo omkhulu [30 mg/(㎏·day)] usetshenziswa kumagundane esifazane nakonogwaja besifazane.Nokukhubazeka kwamathambo.
Ukusetshenziswa kanye Nesilinganiso
Isekelwe ku-albendazole.Ukuphathwa ngomlomo: kanye, 25 ~ 50mg / kg isisindo somzimba.Noma landela iseluleko sikadokotela.
Ukusabela Okubi
(1) lapho izinja zinikezwa ama-50 mg/kg kabili ngosuku, kancane kancane zaziba ne-anorexia
(2) Ukusetshenziswa kwe-albendazole ekuqaleni kokukhulelwa kungahambisana ne-teratogenicity kanye ne-embryotoxicity.
Qaphela
Izilwane kufanele ziqaphe ezinsukwini zokuqala ezingama-45 ngemuva kokukhulelwa
I-Hebei Veyong Pharmaceutical Co., Ltd, yasungulwa ngo-2002, etholakala eShijiazhuang City, eSifundazweni saseHebei, eChina, eduze kweNhloko-dolobha yaseBeijing.Uyibhizinisi elikhulu lemithi yezilwane eqinisekiswe yi-GMP, ene-R&D, ukukhiqizwa nokudayiswa kwama-API wezilwane, amalungiselelo, okuphakelayo okuxutshwe ngaphambili nezithasiselo zokudla.NjengeSikhungo Sezobuchwepheshe Sesifundazwe, i-Veyong isungule uhlelo olusha lwe-R&D lomuthi omusha wezilwane, futhi iyibhizinisi lezobuchwepheshe elaziwa kuzwelonke elisekelwe kudokotela wezilwane, kunochwepheshe abangama-65.I-Veyong inezisekelo ezimbili zokukhiqiza: i-Shijiazhuang ne-Ordos, lapho isisekelo se-Shijiazhuang sihlanganisa indawo engu-78,706 m2, nemikhiqizo ye-API engu-13 ehlanganisa i-Ivermectin, i-Eprinomectin, i-Tiamulin Fumarate, i-Oxytetracycline hydrochloride ects, kanye ne-11, imigqa yokukhiqiza ye-powder yokulungiselela , premix, bolus, izibulala-zinambuzane nesibulala-magciwane, njll.I-Veyong ihlinzeka ngama-API, amalungiselelo angaphezu kwe-100 elebula uqobo, kanye nesevisi ye-OEM & ODM.
I-Veyong ibheka ukubaluleka okukhulu ekuphathweni kohlelo lwe-EHS(Imvelo, Impilo Nokuphepha), futhi yathola izitifiketi ze-ISO14001 ne-OHSAS18001.I-Veyong isohlwini lwamasu amabhizinisi ezimboni asafufusa esifundazweni sase-Hebei futhi ingaqinisekisa ukuhlinzekwa okuqhubekayo kwemikhiqizo.
I-Veyong yasungula uhlelo oluphelele lokuphatha ikhwalithi, yathola isitifiketi se-ISO9001, isitifiketi se-China GMP, isitifiketi se-APVMA GMP yase-Australia, isitifiketi se-Ethiopia GMP, isitifiketi se-Ivermectin CEP, futhi yaphumelela ukuhlolwa kwe-US FDA.I-Veyong inethimba elichwepheshile lokubhalisa, ukuthengisa kanye nenkonzo yezobuchwepheshe, inkampani yethu ithole ukwethenjwa nokusekelwa kumakhasimende amaningi ngekhwalithi yomkhiqizo omuhle kakhulu, ikhwalithi ephezulu yokuthengisa kwangaphambili kanye nenkonzo yangemuva kokuthengisa, ukuphathwa okungathi sína nokwesayensi.I-Veyong yenze ukubambisana kwesikhathi eside namabhizinisi amaningi emithi yezilwane aziwa emhlabeni wonke ngemikhiqizo ethunyelwa eYurophu, eNingizimu Melika, eMpumalanga Ephakathi, e-Afrika, e-Asia, njll. emazweni nasezifundeni ezingaphezu kuka-60.