250mg Triclabendazole Bolus
Izenzo Zemithi
I-Pharmacodynamics I-Triclobendazole ingeyesigaba sezidakamizwa ze-benzimidazole, isetshenziswa ngokukhethekile ukumelana ne-Fasciola hepatica, futhi inomphumela osobala wokubulala ku-Fasciola hepatica yeminyaka eyahlukene.umuthi we-fluke.Ngemuva kokuthi umuthi usumuncwa, uphazamisa ukwakheka kwe-microtubule kanye nomsebenzi we-parasite, Ivimbela ukukhululwa kwe-parasite hydrolytic proteases.Umthelela we-triclobendazole ezikelemu uyahlukahluka ngokuya ngokugxila, njengabantu abadala emazingeni aphansi (1 ~ 3μg/ml)
Isidakamizwa sisaphila amahora angu-24, futhi umsebenzi ubuthakathaka kakhulu ekugxilweni okuphezulu (10-25μg / ml) amahora angu-24;ukuhlushwa okuphezulu kwe-25-50μg/ml kuyivimbela ngokuphelele amahora angama-24.Kodwa kuzwela kakhulu izikelemu.Ku-10 μg/ml, wonke umsebenzi wamahora angu-24 wawuvinjelwe.
I-Pharmacokinetics
I-bioavailability ye-triclobendazole iphezulu.Ngemuva kokuphathwa ngomlomo ka-10 mg/kg wesisindo somzimba ezimbuzini nasezimvini, umuthi ophakeme we-plasma wafinyelela ku-15 μg/ml emahoreni angama-24 kuye kwangama-36, futhi amazinga egazi we-triclobendazole nama-metabolites ayo ayephezulu.Inani eliphakeme lomuthi liphindwe izikhathi ezi-5 kuye kwezingama-20 kunezinye i-benzimidazole anthelmintics, futhi ukukhishwa kwesigamu sempilo cishe amahora angama-22.I-Triclobendazole ifakwe i-oxidized ezimvini nasemagundaneni ibe yi-sulfone ne-sulfokside derivatives, ebophezela ku-albumin futhi iqhubeke ku-plasma izinsuku ezingaphezu kwezingu-7.Ukugxila okuphezulu kwe-plasma nokubopha ku-albhamuin ye-plasma kubonakala kuhlotshaniswa nesikhathi eside sokusebenza kwe-antifascioli.Ngemuva kwezinsuku eziyi-10 zokuphathwa kwezidakamizwa ezimvini, cishe u-95% womuthi ukhishwa endle, u-2% ukhishwa ngomchamo, futhi ngaphansi kuka-1% ukhishwa obisini.
Izenzo kanye nokusetshenziswa
I-Benmidazole anti-fasciola umuthi.Isetshenziselwa ikakhulukazi ukuvimbela nokwelashwa kwe-Fasciola hepatica infection ezinkomeni nasezimvini.
Ukusabela okubi
Akukho ukusabela okubi okuye kwabonwa uma isetshenziswa ngokuya ngokusetshenziswa okunqunyiwe kanye nomthamo
Izinyathelo zokuzivikela
(1) Ikhubazekile ngesikhathi sokukhiqiza ubisi.
(2) Kunobuthi obukhulu ekudobeni, futhi isitsha esisele somuthi akufanele singcolise umthombo wamanzi.
(3) Abantu abangazwani nemithi kufanele bagweme ukuthintana ngqo nesikhumba kanye nokuhogela lapho beyisebenzisa, bagqoke amagilavu lapho bephuza imithi, futhi bakwenqabele ukudla, ukuphuza nokubhema.
(4) Geza izandla ngemva kokufaka isicelo
Isikhathi sokuhoxa
Izinsuku ezingama-56 zezinkomo nezimvu
Isitoreji
Gcina endaweni engaphansi kuka-30 ℃.
I-Hebei Veyong Pharmaceutical Co., Ltd, yasungulwa ngo-2002, etholakala eShijiazhuang City, eSifundazweni saseHebei, eChina, eduze kweNhloko-dolobha yaseBeijing.Uyibhizinisi elikhulu lemithi yezilwane eqinisekiswe yi-GMP, ene-R&D, ukukhiqizwa nokudayiswa kwama-API wezilwane, amalungiselelo, okuphakelayo okuxutshwe ngaphambili nezithasiselo zokudla.NjengeSikhungo Sezobuchwepheshe Sesifundazwe, i-Veyong isungule uhlelo olusha lwe-R&D lomuthi omusha wezilwane, futhi iyibhizinisi lezobuchwepheshe elaziwa kuzwelonke elisekelwe kudokotela wezilwane, kunochwepheshe abangama-65.I-Veyong inezisekelo ezimbili zokukhiqiza: i-Shijiazhuang ne-Ordos, lapho isisekelo se-Shijiazhuang sihlanganisa indawo engu-78,706 m2, nemikhiqizo ye-API engu-13 ehlanganisa i-Ivermectin, i-Eprinomectin, i-Tiamulin Fumarate, i-Oxytetracycline hydrochloride ects, kanye ne-11, imigqa yokukhiqiza ye-powder yokulungiselela , premix, bolus, izibulala-zinambuzane nesibulala-magciwane, njll.I-Veyong ihlinzeka ngama-API, amalungiselelo angaphezu kwe-100 elebula uqobo, kanye nesevisi ye-OEM & ODM.
I-Veyong ibheka ukubaluleka okukhulu ekuphathweni kohlelo lwe-EHS(Imvelo, Impilo Nokuphepha), futhi yathola izitifiketi ze-ISO14001 ne-OHSAS18001.I-Veyong isohlwini lwamasu amabhizinisi ezimboni asafufusa esifundazweni sase-Hebei futhi ingaqinisekisa ukuhlinzekwa okuqhubekayo kwemikhiqizo.
I-Veyong yasungula uhlelo oluphelele lokuphatha ikhwalithi, yathola isitifiketi se-ISO9001, isitifiketi se-China GMP, isitifiketi se-APVMA GMP yase-Australia, isitifiketi se-Ethiopia GMP, isitifiketi se-Ivermectin CEP, futhi yaphumelela ukuhlolwa kwe-US FDA.I-Veyong inethimba elichwepheshile lokubhalisa, ukuthengisa kanye nenkonzo yezobuchwepheshe, inkampani yethu ithole ukwethenjwa nokusekelwa kumakhasimende amaningi ngekhwalithi yomkhiqizo omuhle kakhulu, ikhwalithi ephezulu yokuthengisa kwangaphambili kanye nenkonzo yangemuva kokuthengisa, ukuphathwa okungathi sína nokwesayensi.I-Veyong yenze ukubambisana kwesikhathi eside namabhizinisi amaningi emithi yezilwane aziwa emhlabeni wonke ngemikhiqizo ethunyelwa eYurophu, eNingizimu Melika, eMpumalanga Ephakathi, e-Afrika, e-Asia, njll. emazweni nasezifundeni ezingaphezu kuka-60.