250mg triclabendazole bolus
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Izenzo zekhemisi
I-Pharmacodynamics Triclobendazole ingesigaba se-benzimidazole sezidakamizwa, isetshenziselwa ngokukhethekile ukumelana ne-fascioola hepatica, futhi inomphumela wokubulala okusobala ku-fascioola hepatica yeminyaka ehlukahlukene. Umuthi we-fluke. Ngemuva kokuthi umuthi umunwe, uvumelane nokwakheka kwe-microtuvule kanye nomsebenzi we-parasite, kuvimbela ukukhishwa kwama-proteries e-parasite hydrolytic. Umphumela weTriclobendazole ezibuthweni uyahlukahluka, njengabantu abadala ekugxilweni okuphansi (1 ~ 3μ / ml)
Umuthi usasinda amahora angama-24, futhi umsebenzi ubuthakathaka kakhulu ekuhlushweni okuphezulu (10-25μg / mL) amahora angama-24; Ukuhlushwa okuphezulu kwe-25-50μ / ml kuvimbela ngokuphelele amahora angama-24. Kepha uzwela kakhulu izibungu. Ku-10 μg / ml, wonke umsebenzi wamahora angama-24 wavinjelwa.
Pharmacokinetics
I-Bioavailability yeTriclobendazole iphakeme. Ngemuva kokuphathwa ngomlomo kwesisindo somzimba we-10 mg / kg ezimbuzini nasezimeni, umuthi we-Plasma ophakeme ofinyelelwe ku-15 μg / ml ngamahora angama-24 kuye kwangama-36, futhi amazinga egazi e-triclobexwale nama-metabolites awo ayephakeme. Inani eliphakeme lesidakamizwa liphi izikhathi ezi-5 kuye kwezingama-20 ezingezinye ze-benzimidazole anthelmintics, kanye nokuqedwa kwe-HALF Life kungamahora angama-22. I-Triclobendazole ifakwe kakhulu kwizimvu namagundane kuya kusibalfone kanye ne-sulfoxide derivatives, ebopha i-albhamuin futhi aphikelele ku-plasma isikhathi esingaphezu kwezinsuku eziyi-7. Ukugxila okuphezulu kwe-plasma nokubopha i-plasma albhamu kubonakale kuhlotshaniswa nesikhathi eside sesenzo se-antifaskuli. Ngemuva kwezinsuku eziyi-10 zokuphathwa kwezidakamizwa ezimvini, cishe ama-95% ezidakamizwa afakwa ku-feeces, ama-2% afakwa ku-umchamo, futhi ngaphansi kwe-1% kufakwa obisini.
Izenzo nokusebenzisa
Benzimidazole anti-fasciola dopula. Isetshenziselwa ikakhulukazi ukuvimbela kanye nokwelashwa kokutheleleka kwe-Fasciola Hepatica ezinkomeni nasezimvu.
Ukuphendula Okubi
Akunakusabela okuphikisayo okuye kwabonakala lapho kusetshenziswa ngokuya ukusetshenziswa okubekiwe kanye nomthamo
Izinyathelo zokuzivikela
(1) Kukhutshaziwe ngesikhathi sokukhiqizwa kobisi.
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(3) Abantu abangezwani nemithi kufanele bagweme ukuxhumana ngqo kwesikhumba nokuphefumula lapho besebenzisa, gqoka amagilavu lapho bephuza, futhi benqabela ukudla, ukuphuza nokubhema.
(4) Geza izandla ngemuva kokufaka isicelo
Isikhathi sokuhoxisa
Izinsuku ezingama-56 zezinkomo nezimvu
Ukubeka
Gcina endaweni engezansi 30 ℃.
UHebei Veyong Pharmaceutical Co, Ltd, wasungulwa ngonyaka ka-2002, etholakala eShijiazhuang City, esifundeni saseHebei, eChina, eduze kwenhloko-dolobha eBeijing. Uyibhizinisi elikhulu lezidakamizwa eliqinisekisiwe le-GMP, nge-R & D, ukukhiqizwa kanye nokuthengiswa kwama-apis wezilwane, amalungiselelo, okuphakelayo okubekiwe kanye nokuphakelwa izengezo. Njengesikhungo sezobuchwepheshe sesifundazwe, uVeyong usungule uhlelo olusha lwe-R & D lwe-New Veterinary Drug, futhi yiwona we-technological annology ebhizinisini elisuselwa kubuchwepheshe, kukhona ochwepheshe bezobuchwepheshe abangama-65. UVeyong unezisekelo ezimbili zokukhiqiza: I-Shijuazhuang kanye ne-Ordos, lapho iShijuazhuange isiza ifaka indawo engu-78,706 m2, i-Oxytetracycline imigqa yokukhiqiza kubandakanya i-ivermectin, i-olytetracycline imigqa yokukhiqiza kubandakanya umjovo, i-bolus, ama-pesticides kanye amagciwane, amahlelo. UVeyong unikeza ama-API, amalungiselelo angaphezu kwe-100 anamalebula, kanye nensizakalo ye-OEM & ODM.
UVeyong unamathela ngokubaluleka okukhulu ekuphathweni kwe-EHS (imvelo, ezempilo kanye nokuphepha), futhi uthole izitifiketi ze-ISO14001 nezi- ohsas180000. UVeyong ubhalwe phansi kumabhizinisi wezimboni asafufusa izimboni esifundazweni saseHebei futhi angaqinisekisa ukunikezwa kwemikhiqizo okuqhubekayo.
UVeyong wasungula uhlelo oluphelele lokuphathwa kwekhwalithi, ethola isitifiketi se-ISO9001, isitifiketi se-China GMP, isitifiketi se-APHVMA GMP, isitifiketi se-Ethiopia GMP, isitifiketi se-Ivermectin CEP, futhi sadlula ukuhlolwa kwe-US FDA. UVeyong uneqembu eliqeqeshiwe lokurejista, ukuthengisa kanye nenkonzo yezobuchwepheshe, inkampani yethu ithole ukuthembela nokusekelwa okuvela kumakhasimende amaningi ngekhwalithi ephezulu yomkhiqizo, insizakalo ephezulu yokuthengisa kanye nokuthengisa okuthengiswayo, ukuphathwa okungathi sína. UVeyong wenze ukubambisana isikhathi eside ngamabhizinisi amaningi ezaziwayo ezingezemikhiqizo athunyelwe eYurophu, eSouth America, eMpumalanga Ephakathi, e-Eshiya, e-ESIA, amazwe angaphezu kwangu-60.
