0.2% IVERMECTIN DRENCH
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Isenzo se-Pharmacological
Ivermectinikakhulukazi inomphumela omuhle we-anthelmintic kuma-nematode nama-arthropods angaphezulu ku-vivo.Indlela yayo ye-anthelmintic ukukhuthaza ukukhululwa kwe-γ-aminobutyric acid (GABA) kuma-presynaptic neurons, ngaleyo ndlela kuvule iziteshi ze-GABA-mediated chloride.I-Ivermectin iphinde ikhethe futhi isondelene kakhulu namashaneli e-chloride e-glutamate-mediated atholakala eduze kwezindawo ze-GABA-mediated ku-invertebrate nerve kanye namaseli emisipha, ngaleyo ndlela iphazamise ukudluliselwa kwesignali phakathi kwemisipha ye-neuromuscular nokuphumula nokukhubaza i-parasite, okuholela ekufeni kwe-parasite noma ukuxoshwa umzimba.Ama-interneurons avimbelayo kanye nama-motoneurons ajabulisayo ama-C. elegans amasayithi azo asebenza kuwo, kuyilapho indawo yesenzo sama-arthropods iyindawo yokuhlangana kwe-neuromuscular.Iphinde isebenze ngokumelene nama-arthropods, njengezimpethu, izibungu, nezintwala.omdala i-Coronaria dentata kanye nezilokazane ezingavuthiwe ezingulubeni, iphinde isebenze ngokwedlulele ku-Trichinella spiralis emathunjini (ayisebenzi ku-intramuscular Trichinella spiralis), futhi inomphumela omuhle wokulawula ezintwaleni zegazi lezingulube kanye ne-Sarcoptes scabiei.Ayisebenzi ngokumelene nama-trematodes kanye nama-tapeworms.
I-Pharmacokinetics
I-pharmacokinetics yeivermectinziyahlukahluka ngokuphawulekayo kuye ngohlobo lwezilwane, ifomu lomthamo, kanye nomzila wokuphatha.I-bioavailability yomjovo we-subcutaneous iphakeme kunaleyo yokuphathwa ngomlomo, kodwa ukuphathwa ngomlomo kungena ngokushesha kunomjovo ongaphansi kwesikhumba.Ngemva kokumuncwa, ingasatshalaliswa kahle ezicutshini eziningi, kodwa akulula ukungena ku-cerebrospinal fluid.Umthamo obonakalayo wokusatshalaliswa kwezimvu nezingulube ngu-4.6 no-4 L/kg, ngokulandelana.Inesigamu sempilo ende ezilwaneni eziningi, izinsuku ezi-2 kuya kweziyisi-7 kanye nezinsuku eziyi-0.5 ezimvini nasezingulubeni, ngokulandelana.Lo mkhiqizo we-metabolized esibindini, ikakhulukazi i-hydroxylated ezimvini, futhi ikakhulukazi i-methylated ezingulubeni.Ikhishwa kakhulu endle futhi ngaphansi kuka-5% ikhishwa ingashintshiwe noma njengama-metabolites emchameni.Emadamini ancancisayo, u-5% womthamo ukhishwa obisini.
Ukusebenzisana Kwezidakamizwa
Ukusetshenziswa kanyekanye ne-diethylcarbamazine kungadala i-encephalopathy enzima noma ebulalayo.
Isenzo nokusetshenziswa
Izidakamizwa ze-antiparasite ye-Macrolide.Isetshenziselwa ukulawula i-nematode, i-acariasis kanye nezifo zezinambuzane zezimvu nezingulube.
Umthamo kanye nokuphatha
Ngomlomo: umthamo owodwa, u-0.1 ml wezimvu kanye no-0.15 ml wezingulube nge-1 kg yesisindo somzimba.
Ukusabela okubi
Akukho ukusabela okubi okuye kwabonwa lapho kusetshenziswa ngokuya ngomthamo obekiwe kanye nomthamo.
Izinyathelo zokuzivikela
(1) Ayivunyelwe ngesikhathi sokuncelisa.
(2) Kufanele isetshenziswe ngokuqapha ezingulubeni ezingulubeni phakathi nezinsuku zokuqala ezingu-45 zokukhulelwa.
(3) Izimfanzi ze-Ivermectin, izinhlanzi nezinto eziphila emanzini zinobuthi kakhulu, futhi ukupakishwa neziqukathi zemithi eyinsalela akufanele kungcolise imithombo yamanzi.
Isikhathi sokuhoxiswa: izinsuku ezingama-35 ezimvini kanye nezinsuku ezingama-28 ezingulubeni.
Isikhathi sokuhoxa
izinsuku ezingama-35 ezimvini nezinsuku ezingama-28 ezingulubeni.
I-Hebei Veyong Pharmaceutical Co., Ltd, yasungulwa ngo-2002, etholakala eShijiazhuang City, eSifundazweni saseHebei, eChina, eduze kweNhloko-dolobha yaseBeijing.Uyibhizinisi elikhulu lemithi yezilwane eqinisekiswe yi-GMP, ene-R&D, ukukhiqizwa nokudayiswa kwama-API wezilwane, amalungiselelo, okuphakelayo okuxutshwe ngaphambili nezithasiselo zokudla.NjengeSikhungo Sezobuchwepheshe Sesifundazwe, i-Veyong isungule uhlelo olusha lwe-R&D lomuthi omusha wezilwane, futhi iyibhizinisi lezobuchwepheshe elaziwa kuzwelonke elisekelwe kudokotela wezilwane, kunochwepheshe abangama-65.I-Veyong inezisekelo ezimbili zokukhiqiza: i-Shijiazhuang ne-Ordos, lapho isisekelo se-Shijiazhuang sihlanganisa indawo engu-78,706 m2, nemikhiqizo ye-API engu-13 ehlanganisa i-Ivermectin, i-Eprinomectin, i-Tiamulin Fumarate, i-Oxytetracycline hydrochloride ects, kanye ne-11, imigqa yokukhiqiza ye-powder yokulungiselela , premix, bolus, izibulala-zinambuzane nesibulala-magciwane, njll.I-Veyong ihlinzeka ngama-API, amalungiselelo angaphezu kwe-100 elebula uqobo, kanye nesevisi ye-OEM & ODM.
I-Veyong ibheka ukubaluleka okukhulu ekuphathweni kohlelo lwe-EHS(Imvelo, Impilo Nokuphepha), futhi yathola izitifiketi ze-ISO14001 ne-OHSAS18001.I-Veyong isohlwini lwamasu amabhizinisi ezimboni asafufusa esifundazweni sase-Hebei futhi ingaqinisekisa ukuhlinzekwa okuqhubekayo kwemikhiqizo.
I-Veyong yasungula uhlelo oluphelele lokuphatha ikhwalithi, yathola isitifiketi se-ISO9001, isitifiketi se-China GMP, isitifiketi se-APVMA GMP yase-Australia, isitifiketi se-Ethiopia GMP, isitifiketi se-Ivermectin CEP, futhi yaphumelela ukuhlolwa kwe-US FDA.I-Veyong inethimba elichwepheshile lokubhalisa, ukuthengisa kanye nenkonzo yezobuchwepheshe, inkampani yethu ithole ukwethenjwa nokusekelwa kumakhasimende amaningi ngekhwalithi yomkhiqizo omuhle kakhulu, ikhwalithi ephezulu yokuthengisa kwangaphambili kanye nenkonzo yangemuva kokuthengisa, ukuphathwa okungathi sína nokwesayensi.I-Veyong yenze ukubambisana kwesikhathi eside namabhizinisi amaningi emithi yezilwane aziwa emhlabeni wonke ngemikhiqizo ethunyelwa eYurophu, eNingizimu Melika, eMpumalanga Ephakathi, e-Afrika, e-Asia, njll. emazweni nasezifundeni ezingaphezu kuka-60.
