0.2% i-ivermectin drench
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Isenzo samakhemisi
IvermectinNgokuyinhloko unomphumela omuhle we-anthelmintic kuma-nematode nama-arthropods angaphezulu komhlaba eVivo. Indlela yayo ye-anthelmintic ukukhuthaza ukukhishwa kwe-γ-aminobutyric acid (Gaba) kusuka kuma-neurons aphambukayo, ngaleyo ndlela avule iziteshi ze-chloride ze-gaba. I-Ivermectin ibuye ikhethe futhi inobudlelwano obuphezulu beziteshi ze-chlotarate-mediated chloramate eziseduze kwamasayithi we-Gaba-Mediated ku-Invortebrate nerve kanye namaseli emisipha, ukhubazeke futhi ukhubaze ukufutheka, okuholela ekufeni komhlaba. Ama-inhibitory interteurons nama-motoneones e-C. Eleshans yizindawo zawo zesenzo, kuyilapho indawo yesenzo ye-arthropods ingumbungu we-neuromuscular. Kuyasebenza futhi ngokulwa nama-arthropods, njengezimpethu ezindizayo, izibungu kanye nezintwala. I-Adult Coronaria Dentata kanye nama-parasites angavuthiwe ezingulubeni, futhi kusebenza kakhulu eTrichinella Spialis kumathumbu (ayisebenzi nge-intramuscular trichinella simanga), futhi inomphumela omuhle wokulawula ku-Pip Geadi Gice kanye neSarcoptes Scabiei. Akusebenzi ngokumelene nama-trematode nama-tapeworms.
Pharmacokinetics
Ama-pharmacokinetics weIvermectinYehlukahluka ngokungenamaki ngokuya ngezinhlobo zezilwane, ifomu lomthamo, nendlela yokuphatha. I-Bioavailability yomjovo ongaphansi iphakeme kunaleso sokuphatha ngomlomo, kepha ukuphathwa ngomlomo kudonswa ngokushesha kunomjovo ongaphansi. Ngemuva kokudonswa, kungasatshalaliswa kahle kwizicubu eziningi, kepha akulula ukufaka uketshezi lwe-cerebrospinal. Ivolumu ebonakalayo yokusatshalaliswa kwezimvu nezingulube ingu-4.6 no-4 l / kg, ngokulandelana. Inempilo ende ende ezilwaneni eziningi, izinsuku ezi-2 kuya kwezingu-7 nezinsuku eziyi-0,5 ezimvini nezingulube, ngokulandelana. Lo mkhiqizo uhlanganiswe esibindini, ikakhulukazi ama-hydroxylated ezimvini, futhi ikakhulukazi methylated ezingulubeni. Kufakwe ikakhulu ezindlebeni futhi ngaphansi kwama-5% kukhishwa kungashintshiwe noma njenge-metabolites emchameni. Emadamini akhukhuzayo, ama-5% omthamo afakiwe obisini.
Ukusebenzisana kwezidakamizwa
Ukusetshenziswa okuhlangene nge-diethylcarbamazine kungakhiqiza i-encephalopathy enzima noma ebulalayo.
Isenzo nokusetshenziswa
Ama-macrolide antiparasitic izidakamizwa. Isetshenziselwa ukulawula i-nematode, i-acarisis kanye nezifo zezinambuzane zezinambuzane ezihlahleni nasezingubeni.
Umthamo nokuphatha
I-Oral: umthamo owodwa, u-0,1 ml wezimvu no-0.15 ml ngezingulube nge-1 kg yesisindo somzimba.
Ukuphendula Okubi
Akunakusabela okuphikisayo okuqashelwe lapho kusetshenziswa ngokuya ngokusetshenziswa okucacisiwe kanye nomthamo.
Izinyathelo zokuzivikela
(1) Ingqubuzana ngesikhathi se-lactation.
(2) Kufanele isetshenziswe ngokuqapha ekutholeni izinsuku zokuqala ezingama-45 zokukhulelwa.
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Isikhathi sokuhoxa: Izinsuku ezingama-35 zezimvu nezinsuku ezingama-28 zezingulube.
Isikhathi sokuhoxisa
Izinsuku ezingama-35 zezinsuku ezingama-28 zezingulube.
UHebei Veyong Pharmaceutical Co, Ltd, wasungulwa ngonyaka ka-2002, etholakala eShijiazhuang City, esifundeni saseHebei, eChina, eduze kwenhloko-dolobha eBeijing. Uyibhizinisi elikhulu lezidakamizwa eliqinisekisiwe le-GMP, nge-R & D, ukukhiqizwa kanye nokuthengiswa kwama-apis wezilwane, amalungiselelo, okuphakelayo okubekiwe kanye nokuphakelwa izengezo. Njengesikhungo sezobuchwepheshe sesifundazwe, uVeyong usungule uhlelo olusha lwe-R & D lwe-New Veterinary Drug, futhi yiwona we-technological annology ebhizinisini elisuselwa kubuchwepheshe, kukhona ochwepheshe bezobuchwepheshe abangama-65. UVeyong unezisekelo ezimbili zokukhiqiza: I-Shijuazhuang kanye ne-Ordos, lapho iShijuazhuange isiza ifaka indawo engu-78,706 m2, i-Oxytetracycline imigqa yokukhiqiza kubandakanya i-ivermectin, i-olytetracycline imigqa yokukhiqiza kubandakanya umjovo, i-bolus, ama-pesticides kanye amagciwane, amahlelo. UVeyong unikeza ama-API, amalungiselelo angaphezu kwe-100 anamalebula, kanye nensizakalo ye-OEM & ODM.
UVeyong unamathela ngokubaluleka okukhulu ekuphathweni kwe-EHS (imvelo, ezempilo kanye nokuphepha), futhi uthole izitifiketi ze-ISO14001 nezi- ohsas180000. UVeyong ubhalwe phansi kumabhizinisi wezimboni asafufusa izimboni esifundazweni saseHebei futhi angaqinisekisa ukunikezwa kwemikhiqizo okuqhubekayo.
UVeyong wasungula uhlelo oluphelele lokuphathwa kwekhwalithi, ethola isitifiketi se-ISO9001, isitifiketi se-China GMP, isitifiketi se-APHVMA GMP, isitifiketi se-Ethiopia GMP, isitifiketi se-Ivermectin CEP, futhi sadlula ukuhlolwa kwe-US FDA. UVeyong uneqembu eliqeqeshiwe lokurejista, ukuthengisa kanye nenkonzo yezobuchwepheshe, inkampani yethu ithole ukuthembela nokusekelwa okuvela kumakhasimende amaningi ngekhwalithi ephezulu yomkhiqizo, insizakalo ephezulu yokuthengisa kanye nokuthengisa okuthengiswayo, ukuphathwa okungathi sína. UVeyong wenze ukubambisana isikhathi eside ngamabhizinisi amaningi ezaziwayo ezingezemikhiqizo athunyelwe eYurophu, eSouth America, eMpumalanga Ephakathi, e-Eshiya, e-ESIA, amazwe angaphezu kwangu-60.
